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FILE - In this June 27, 2006 file photo, reviewed by a U.S. Department of Defense official, U.S. military guards walk within Camp Delta military-run prison, at the Guantanamo Bay U.S. Naval Base, Cuba. The White House is threatening that President Barack Obama would veto the defense bill unless Congress makes changes. The Office of Management and Budget issued a statement Thursday as the Senate debated the $631 billion bill. Specifically, the White House complained about provisions restricting the administration's ability to transfer detainees from the U.S. Naval facility at Guantanamo Bay, Cuba, to foreign countries. The White House also complained about the prohibition on funds to build a detention facility in the US. (AP Photo/Brennan Linsley, File)
FILE - In this June 27, 2006 file photo, reviewed by a U.S. Department of Defense official, U.S. military guards walk within Camp Delta military-run prison, at the Guantanamo Bay U.S. Naval Base, Cuba. The White House is threatening that President Barack Obama would veto the defense bill unless Congress makes changes. The Office of Management and Budget issued a statement Thursday as the Senate debated the $631 billion bill. Specifically, the White House complained about provisions restricting the administration's ability to transfer detainees from the U.S. Naval facility at Guantanamo Bay, Cuba, to foreign countries. The White House also complained about the prohibition on funds to build a detention facility in the US. (AP Photo/Brennan Linsley, File)
WASHINGTON (AP) ? The Senate has voted to accelerate the withdrawal of U.S. forces from Afghanistan.
The 62-33 vote on Thursday reflected the nation's war-weariness after more than a decade of fighting.
Although the vote was for a nonbinding amendment to the defense bill, it sent a strong signal about the ongoing conflict. Democratic Sen. Jeff Merkley of Oregon sponsored the measure.
It also set the stage for a fight with the House, which passed a bill in May that calls for President Barack Obama to maintain a force of at least 68,000 troops through the end of 2014.
The House and Senate will have to reconcile their competing versions of the defense policy bill.
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Wello
Some impressive investors including Mayo Ventures, Kleiner Perkins, Mohr Davidow and Aberdare Ventures have thrown $1 million in seed money behind an ambitious Rock Health fitness startup by the name of Wello.
The startup has created an online marketplace that connects physical trainers with clients and enables live, online personal training via video chat.
The seed round, which also saw contributions from Morado Ventures, S-Cubed Capital, PhilQuo Ventures and angel investors, will propel the startup as it readies to launch a new offering early next year.
Right now, Wello facilitates personalized, one-on-one training sessions between consumers and more than 150 certified physical trainers. The next step is to launch fitness classes led by those trainers so that users can do joint sessions with family or friends in different places, or join a structured class with others who are interested in the same activity and are available at the same time. That would bring down the cost of a session, co-founder Leslie Silverglide noted, which ranges from $35 to $199 per hour depending on the trainer.
For consumers, the value proposition is obvious: more motivation to work out and help from someone who knows what they?re doing, without having to leave home. The site lets users search for trainers based on style and specialty. For trainers, Wello provides an additional revenue stream and the potential to fill typically unbooked hours during the day with appointments. Trainers are screened by the company?s on-staff personal trainer and must take a class on how to train through video.
Wello takes a part of the per-session payment, but not nearly as much as the up-to-80 percent that gyms take from trainers? fees, Silverglide said. That enables trainers to charge less for a session.
Silverglide and co-founder Ann Scott Plante met as business students at Stanford University and started working on the site at the beginning of 2011. They launched it in a private beta mode in March of this year and publicly in July.
They won?t say just how many people are using the site, but they will say that those that use it tend to return. ?Two-thirds of people that try a session once will come on and try it again,? Plante said, adding that some customers have already done up to 50 sessions in the four months the site has been live.
As far as competition goes, the closest thing to Wello appears to be HealthFleet Inc., a Connecticut e-coaching startup for weight loss. But Wello is probably tapping into the same pool of people who would use services or mobile tools that track and personalize health recommendations like FitKit, Healthrageous and Enforcer eCoaching.
Although the founders are spending their time in Rock Health?s incubator program developing and preparing to launch the new features next year, they aren?t planning on stopping there. ?Ultimately we hope to connect people with experts in nutrition, sports therapy, etc.,? Silverglide said.
[Image courtesy Wello]
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Tuesday, Nov. 27, 2012 Ottawa -- Yellow police tape surrounds the gutted apartment where one person died in a fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. Ottawa Police say it's a homicide investigation. DANIELLE BELL/OTTAWA SUN/QMI AGENCY
Scene of a fatal fire at 90 Woodridge Crescent in Ottawa. Tuesday November 27,2012. Errol McGihon/Ottawa Sun/QMI Agency
Tuesday, Nov. 27, 2012 Ottawa -- Yellow police tape surrounds the gutted apartment where one person died in a fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. Ottawa Police say it's a homicide investigation. DOUG HEMPSTEAD/OTTAWA SUN/QMI AGENCY
Scene of a fatal fire at 90 Woodridge Crescent in Ottawa. Tuesday November 27,2012. Errol McGihon/Ottawa Sun/QMI Agency
Tuesday, Nov. 27, 2012 Ottawa -- Yellow police tape surrounds the gutted apartment where one person died in a fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. Ottawa Police say it's a homicide investigation. DANIELLE BELL/OTTAWA SUN/QMI AGENCY
Yellow police tape surrounds the gutted apartment where one person died in a fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. (DANIELLE BELL Ottawa Sun)
Yellow police tape surrounds the gutted apartment where one person died in a fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. (DANIELLE BELL Ottawa Sun)
One person is dead after an apartment fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. (Andrew Tarzwell submitted photo)
One person is dead after an apartment fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. (Andrew Tarzwell submitted photo)
One person is dead after an apartment fire at 90 Woodridge Cres., early on Tuesday, Nov. 27, 2012. (Andrew Tarzwell submitted photo)
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A 30-year-old high school dropout accused of murdering his disabled mother was deemed ?not a significant threat to the safety of the public? two years ago stemming from an attack on his father.
Rene Goudreau, who is charged with first-degree murder of his wheelchair-bound mother, 53-year-old Lucie Goudreau, has a long history of mental illness, including schizoaffective and bipolar disorders, according to Ontario Review Board documents obtained by the Sun.
They paint a troubled picture of Goudreau. According to his own interviews, he experimented with alcohol at 13, marijuana a year later. After dropping out at 19, he bounced between jobs, including tele-marketing, fast food and construction.
He stayed now and again at his mother?s Woodridge Cres. apartment where her body was found after a Tuesday morning morning.
In 2010, after his 56-year-old father Jacques Goudreau died of cancer, he moved back with his mother.
Goudreau had reconciled with his father. He had been ordered to have no contact after he broke down his father?s door and attacked him in 2008.
It started when Jacques locked Rene out, but after the attack and the arrest, his mother let him back into the apartment the next day. In 2008, he was found not criminally responsible on charges of assault causing bodily harm, assault and intent to resist arrest and mischief.
And it was Lucie who told doctors in 2010 she ?very much appreciates? Rene living with her since she has multiple sclerosis and depends on him daily.
The ORB ruled in Oct. 2010 that Goudreau was ?not a significant threat to public safety.?
At the time of the attack, Goudreau was manic, and as long as his symptoms were controlled with medication, the chance of another violent incident was ?unlikely,? the documents stated at the time.
Goudreau started psychiatric care in 2004 at the Ottawa Hospital after being arrested by police for trespassing.
There were other arrests and hospitalizations ? once for breaking a bus window in 2007 and when he was caught running naked down the street.
Goudreau had a history of not taking his medication, mild substance and alcohol abuse, the documents suggest.
In 2001, he was convicted of attempted theft under $5,000 and assault.
In 2008 and 2009, Goudreau was deemed to pose ?a significant threat to the safety of the public.? Several times he was discharged to a subsidized apartment, where conditions included he refrain from alcohol or drugs, not have weapons and submit to random urine samples.
But in 2010, the review board changed its opinion.
Goudreau appeared in Ottawa court on Wednesday, where a judge ordered a 30-day psychiatric assessment to determine if he?s fit to stand trial.
He is not entering a plea, said his lawyer Doug Baum, because ?there?s a concern about his perception of reality and understanding of the proceedings.?
?He does appear to be a little unstable ? I think that is obvious,? Baum said outside court.
?There are some concerns, the court shares them, which is why a psychiatric opinion has been sought.
?He?s been ill for some time.?
Goudreau muttered incoherently during his first court appearance Tuesday, when Baum told the court his client had a history at the Royal Ottawa Hospital Mental Health Centre.
Twitter: @ottawasundbell
? With files from Megan Gillis
Other cases of children killing their parents in the last decade:
? With files from Jessica Beddaoui
?
Source: http://www.ottawasun.com/2012/11/28/psych-assessment-for-man-accused-of-killing-mother
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Indication of how much racism exists in the depths of this country?s psyche (and this includes among supposed upholders of ?law-and-order? such as police, judges, etc.) ?
President Barack Obama is the target of more than 30 potential death threats a day and is being protected by an increasingly over-stretched Secret Service. He is the most threatened President in history.
Since the President took office in 2008, the rate of threats against the president has increased 400% cent. Some threats to the President have been publicized, including the well known alleged plot by white supremacists in Tennessee to rob a gun store, shoot 88 black people, decapitate another 14 and then assassinate the first black president in American history.
?? America is a post-racial society in name and desire only. ?Attitudes toward racial integration have warmed, but in our homes and communities, we?re as segregated as ever; attitudes toward interracial dating have also warmed, but dating patterns remain mostly unchanged, with only 1% of all American marriages taking place between a black and a white person. ?Yet the historic election of President Obama temporarily halted the cloud of racial pessimism that has hovered over our society since the 1600s and followed us through succeeding eras of hard-earned, if altogether underwhelming, progress:
We have 44 African-American Congresspersons (out of 435, or 10%, near-parity), zero black Senators (out of 100), 1 black governor (out of 56), and just 250-500 black mayors (out of 19,000 cities, or 2.6%).
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Stocks closed near session lows in volatile trading Tuesday, with the S&P 500 breaking below 1,400, as ongoing worries over the "fiscal cliff" trumped a batch of positive economic reports and optimism over the Greek deal.
Stocks took another leg lower in the afternoon after Senate Majority Leader Harry Reid said he is disappointed with the little progress made in the recent debt talks. Reid's comments echoed Senator Dick Durbin's cautious statement over the weekend.
The Dow Jones Industrial Average dropped 89.24 points, or 0.69 percent, to end at 12,878.13, dragged by Hewlett-Packard. Intel led the blue-chip gainers.
The S&P 500 declined 7.35 points, or 0.52 percent, to finish at 1,398.94. And the Nasdaq fell 8.99 points, or 0.30 percent, to close at 2,967.79.
The CBOE Volatility Index, widely considered the best gauge of fear in the market, traded above 15.
Most key S&P sectors finished in negative territory, led by banks and energy. Utilities closed higher for a second-straight session.
?Consumer and investors alike are concerned about the fiscal cliff,? said David Kudla, CEO and chief investment strategist at Mainstay Capital Management. ?Market is going to suffer from headline risk until we get to that deal.?
Investors were focused on politicians? efforts to resolve the $600 billion ?fiscal cliff? of automatic tax hikes and spending cuts due to hit the U.S. economy at the end of the year. Negotiations are expected to resume this week as policymakers return to Washington from the Thanksgiving holiday.
European shares were higher after Greece's international creditors secured a deal to reduce the troubled nation's debt by 40 billion euros ($51.9 billion) and changed the debt target for the country to 124 percent of gross domestic product (GDP) by 2020, from 120 percent previously.
?Nothing else matters?everyone is focused on the resolution of the fiscal cliff,? said John Fox, co-manager of the FAM Value Fund. ?Stocks will most likely muddle through until we come to some solution.?
ConAgra agreed to acquire Ralcorp in a deal worth nearly $5 billion to become the biggest private label food company in North America.
Facebook rose to hit a four-month high after Nomura boosted its price target on the social-networking giant to $32 from $27 a share.
Yelp gained after Cantor Fitzgerald raised its rating on the business review site to "buy."
In a quiet day for earnings, home security firm ADT posted better-than-expected earnings and said its board approved a $2 billion share repurchasing program over three years.
Green Mountain and Analog Devices are scheduled to post earnings after the closing bell.
Corning rallied after the glass manufacturer said it sees stronger-than-expected fourth-quarter LCD glass volume and full-year sales of its gorilla glass approaching $1 billion, thanks to robust demand for LCD televisions and other consumer electronic devices in North America and China.
Dollar General will replace Cooper Industries to join the S&P 500 index after the close of trading Friday. The move comes as a result of Eaton's plans to acquire Cooper.
On the economic front, home prices rose for the sixth-consecutive month in September, according to the S&P/Case-Shiller home price index. Meanwhile, consumer confidence rose to its highest level in 4-1/2 years in November, according to the Conference Board.
And durable goods were unchanged in October, according to the Commerce Department.
The government auctioned $35 billion in 2-year notes at a high yield of 0.27 percent. The bid-to-cover was 4.07.
Source: http://www.nbcnews.com/business/stock-end-lower-fiscal-cliff-fears-1C7287490
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Have you ever set up a fresh web site by using an Andre Johnson Jersey internet hosting business? These days, sites are much easier to build, people these days are setting up their very own sites and getting them sponsored. What occurs, although, should you get caught up? It is crucial that you simply select a trustworthy web hosting business that offers great tech support. Keep reading for some advice on other essential factors to consider in choosing an internet web hosting service service.
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A 5-year-old girl was shot in the stomach by a stray bullet after returning home from a baby shower with her family on Sunday, the New York Daily News reports . Scroll down for video of story Haily Dominguez (pictured) is listed in critical but stable condition
Read the original here:
5-Year-Old Shot By Stray Bullet After Leaving Baby Shower With Family
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For free-living organisms, the ability to sense and respond to the outside environment is crucial for survival. Eukaryotes, such as animals and plants, often have highly complex network systems in place to monitor their surroundings and respond effectively, but bacteria have developed a remarkably simple system. It?s called the ?Two Component System? because it literally relies on just two components; a sensor and a responder. The sensor picks up the signal, communicates this to the responder, which then causes the effect.
The components of the two-component signalling system. Picture (c) me.
The picture above shows this process happening. The ?communication? of the message from the sensor to the responder, as shown by the coloured arrows, is carried out by transferring phosphate molecules. The signal interacting with the sensor causes the sensor to autophosphorylate (phosphorylate itself) and then pass the phosphate molecule onto the responder to trigger the response. The letters ?H? and ?D? are the actual amino-acids being phosphorylated; Histadine and Aspartate.
Although Two-Component Systems (TCS) are found in all three superkingdoms of life (archaea, bacteria and eukaryotes) they are suspiciously absent from the animal kingdom. Plants have them, as do fungi and several protazoa, but they just aren?t present in animals. For this reason they?ve been looked into as potential antibiotic targets as knocking out the Two-Component Systems of most bacteria is fatal.
Why don?t animals use TCS? To answer this you have to start looking at the evolution of the system itself, because despite being nominally present in eukaryotes such as plants and fungi, TCS are used very differently. Bacteria use TCS for sensing a wide variety of signals; stress, metabolism, nutrient regulation, chemotaxis, pathogen-host interactions etc. In eukaryotes on the other hand they are used sparingly; for ethylene responses and photosensitivity in plants and osmoregulation in fungi and slime moulds.
Bacteria (especially soil bacteria which have a lot of environment to sense) can contain up to 50 TCS although many internal parasite bacteria contain a lot fewer. The maximum number found in archaea is around 20 and they are even scarer in eukaryotes with only one in bakers yeast (Saccharomyces cerevisiae ? one sensor kinase and three response regulators). None have yet been found in any animal genomes, or in the protist genomes as far as I know (although it is possible recent protist research may have unearthed a few)
Comparing the TCS genes of bacteria, archaea and eukaryotes leads to the interesting conclusion that the bacterial and eukaryotic systems are far more closely related than the archaeal, and in fact are thought to be monophyletic (all evolved from a single common ancestor). In contrast, the archaeal TCS appear to be polyphyletic (several ancestors) and some archaea lack TCS entirely. It?s therefore thought that TCS originated in bacteria and spread by horizontal gene transfer to both archaea and eukaryotes. As horizontal gene transfer relies on DNA moving from one species to another, no further transfer to eukaryotes could occur after they developed larger cells with a nuclear membrane. In eukaryotes very little further diversification took place, whereas the bacterial TCS diversified widely, and occasionally passed new systems back to the archaea. I?ve tried to show this in the diagram below:
The passage of genes for two-component-systems through the three superkingdoms of life
The diagram above attempts to show the movement of the TCS genes through the three superkingdoms of life. Red arrows show the horizontal transfer (straight arrows) and gene duplication (curved arrows) of TCS genes. No horizontal gene transfer can take place in eukaryotes after the nuclear membrane (well?.it can do but is very, very rare) although gene duplication may still have occurred.
The eukaryotic superkingdom appears not to have contained very many of these TCS genes to start with, and the animal kingdom may just have lost the very few it possessed. This makes sense from the point of view of cellular control because while TCS are very useful in bacteria with their small genome and independent lifestyles, it?s less clear how useful they are in eukaryotes as a whole. Introducing a membrane around the nucleus makes it harder for proteins to get in and bind to the DNA, and in a large complicated cell it?s harder for a simple two-component system to sense what?s going on. Added to which, cells inside a multicellular organism don?t really need to sense what?s going on, they get told what?s going on by the surrounding cells and circulating hormones.
Whatever the reason though it is clear that despite this system being vital for bacteria it isn?t used widely, or most likely at all, in animals. Research into this would be particularly useful against opportunistic pathogens which tend to have a large selection of two-component systems to allow them to adapt to different lifestyles depending on the conditions of their immediate environment.
?
Kristin K. Koretke , Andrei N. Lupas , Patrick V. Warren , Martin Rosenberg , and James R. Brown (2000). Evolution of Two-Component Signal Transduction Mol Biol Evol, 17, 1956-1970
Wolanin PM, Thomason PA, & Stock JB (2002). Histidine protein kinases: key signal transducers outside the animal kingdom. Genome biology, 3 (10) PMID: 12372152
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CAIRO (Reuters) - Youths clashed with police in Cairo on Saturday as protests at new powers assumed by President Mohamed Mursi stretched into a second day, confronting Egypt with a crisis that has exposed the split between newly empowered Islamists and their opponents.
A handful of hardcore activists hurling rocks battled riot police in the streets near Tahrir Square, where several thousand protesters massed on Friday to demonstrate against a decree that has rallied opposition ranks against Mursi.
Following a day of violence in Cairo, Alexandria, Port Said and Suez, the smell of teargas hung over the square, the heart of the uprising that swept Hosni Mubarak from power in February 2011.
More than 300 people were injured on Friday. Offices of the Muslim Brotherhood, which propelled Mursi to power, were attacked in at least three cities.
Egypt's highest judicial authority said the decree marked an "unprecedented attack" on the independence of the judiciary, the state news agency reported.
Leftist, liberal and socialist parties have called for an open-ended sit-in with the aim of "toppling" the decree which has also drawn statements of concern from the United States and the European Union. A few dozen activists manning makeshift barricades kept traffic out of the square on Saturday.
Calling the decree "fascist and despotic", Mursi's critics called for a big protest on Tuesday against a move they say has revealed the autocratic impulses of a man jailed by Mubarak, who outlawed Mursi's Muslim Brotherhood.
"We are facing a historic moment in which we either complete our revolution or we abandon it to become prey for a group that has put its narrow party interests above the national interest," the liberal Dustour Party said in a statement.
Issued late on Thursday, the decree marks an effort by the Mursi administration to consolidate its influence after it successfully sidelined Mubarak-era generals in August.
The decree reflects the Muslim Brotherhood's suspicion towards sections of a judiciary unreformed from Mubarak's days: it guards from judicial review decisions taken by Mursi until a new parliament is elected in a vote expected early next year.
It also shields the assembly writing Egypt's new constitution from a raft of legal challenges that have threatened the Islamist-dominated assembly with dissolution.
The Mursi administration has defended the decree on the grounds that it aims to speed up a protracted transition from Mubarak's rule to a new system of democratic government.
"It aims to sideline Mursi's enemies in the judiciary and ultimately to impose and head off any legal challenges to the constitution," said Elijah Zarwan, a fellow with The European Council on Foreign Relations.
"We are in a situation now where both sides are escalating and its getting harder and harder to see how either side can gracefully climb down," Zarwan said.
"INTIFADA"
A central element of Egypt's transition, the drafting of the constitution has been plagued by divisions between Islamists and their more secular-minded opponents, nearly all of whom have withdrawn from the body writing the document.
Mursi's new powers allowed him to replace the prosecutor general - a Mubarak holdover who the new president had tried to replace in October only to kick up a storm of protest from the judiciary, which said he had exceeded his authorities.
At an emergency meeting called to discuss the decree, the Supreme Judicial Council, Egypt's highest judicial authority, urged "the president of the republic to distance this decree from everything that violates the judicial authority".
Al-Masry Al-Youm, one of Egypt's most widely read dailies, hailed Friday's protest as "The November 23 Intifada", invoking the Arabic word for uprising. "The people support the president's decisions," declared Freedom and Justice, the newspaper run by the Brotherhood's political party.
The ultraorthodox Salafi Islamist groups that have been pushing for tighter application of Islamic law in the new constitution have rallied behind the decree.
The Nour Party, one such group, stated its support for the Mursi decree. Al-Gama'a al-Islamiya, which carried arms against the state in the 1990s, said it would save the revolution from what it described as remnants of the Mubarak regime.
Facing the biggest storm of criticism since he won the presidential election in June, Mursi addressed his supporters outside the presidential palace on Friday. He said opposition did not worry him, but it had to be "real and strong".
Candidates defeated by Mursi in the presidential vote joined the protests against his decision on Friday. Former Arab League Secretary General Amr Moussa was photographed linking arms with leftist Hamdeen Sabahi, liberal Mohamed ElBaradei and others.
Mursi is now confronted with a domestic crisis just as his administration won international praise for mediating an end to the eight-day war between Israel and Palestinians in the Gaza Strip.
"The decisions and declarations announced on November 22 raise concerns for many Egyptians and for the international community," State Department spokeswoman Victoria Nuland said in a statement.
The European Union urged Mursi to respect the democratic process, while the United Nations expressed fears about human rights.
Source: http://news.yahoo.com/clashes-cairo-mursi-seizes-powers-063444506.html
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