Wednesday, January 30, 2013

Cartoon Network Is Ditching Upfront Ragers For A ... - Business Insider

Cartoon Network is taking its upfront presentation on the road: In lieu of one supersized Gotham gala, ad sales, marketing and programming execs for the Turner cabler will stop and chat with clients in more than 15 cities around the country to tout Cartoon's fare.

"This year, we are breaking away from a traditional upfront presentation to engage with advertisers in a series of conversations that will focus on the development of ideas that leverage our brand strength to meet the goals of our partners," said Donna Speciale, president of Turner Entertainment and young adults ad sales.

Cartoon is set to premiere a handful of new series in 2013, including action-adventure series based on DC Comics and Warner Bros. Animation: "Teen Titans Go" and "Beware the Batman."

Cabler premiered Nick Cannon-produced sketch comedy skein "Incredible Crew" last week.

Click here for more television news on Variety.com.

Source: http://www.businessinsider.com/cartoon-network-is-ditching-upfront-ragers-for-a-roadshow-2013-1

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Tuesday, January 29, 2013

Gene found that turns up effect of chemotherapy

Jan. 29, 2013 ? Chemotherapy is one of the most common treatments for cancer patients. However, many patients suffer from serious side-effects and a large proportion does not respond to the treatment. Researchers from the Biotech Research and Innovation Centre (BRIC) and Center for Healthy Aging, University of Copenhagen, now show that the gene FBH1 helps turn up the effect of chemotherapy.

The results were recently published in the journal Nature Communications.

"Our results show that the gene FBH1 is crucial in order for some chemotherapeutics to become active in the body and kill the cancer cells. If we can find a feasible method to increase the activity of the gene, we can use our cells' own resources to improve cancer treatment, says associate professor Claus S?rensen who has lead the team of researchers behind the results.

Own gene helps chemotherapy fight cancer

The researchers have used a method called RNA interference to study whether some of the genes in our DNA are important for cancer cells to react to certain chemotherapeutics.

"By using the method to remove single genes from cancer cells and then exposing the cells to chemotherapy, we found that FBH1 is important for the effect of the chemotherapy. Actually, the presence of the gene was an absolutely requirement in order to effectively kill the cancer cells with the type of chemotherapeutics we have studied, says postdoc Kasper Fugger who has led the experimental part of the investigation.

Chemotherapy act by exposing cancer cells to a kind of extreme stress when they divide. The result is detrimental damage to the cells' DNA that cannot be repaired, causing the cells to die. The new results show that it is in fact FBH1 that contributes to the formation of DNA damage when treating with chemotherapy and this knowledge can be used to optimize cancer therapy.

Selection of patients for chemotherapy

In the last decade it has become clear that targeted treatment to individual cancer patients is crucial for an effective treatment with least possible side-effects. By assessing the presence of FBH1 in a tumour the doctors can get an indication of whether the patient will benefit from chemotherapy.

"Our results could help indicate that patients with low or no FBH1 in the cancer cells will not benefit from certain types of chemotherapy, but should be administered another type of treatment. So by using the genetic fingerprint of a tumour doctors can adjust the treatment to individual patients, says Claus S?rensen.

The next step -- finding the FBH1 volume knob

The next step for the research team is to investigate the presence of changes, so-called mutations in FBH1. Identifying mutations rendering cancer cells resistant to certain chemotherapeutics can be used to target the treatment even better to individual patients. Another goal for the researchers is to find a way to turn up the activity of FBH1 in cancer cells.

"Our hope is to find a method to boost the activity of the FBH1 gene in cancer cells since this will make them more sensitive to chemotherapy. Alternatively, we may find a way to simulate an effect similar to that of FBH1, which can be used as additional treatment in order to sensitise cancer cells to chemotherapy. If we achieve this, more patients will benefit from the treatment, says Kasper Fugger.

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The above story is reprinted from materials provided by University of Copenhagen.

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Journal Reference:

  1. Kasper Fugger, Wai Kit Chu, Peter Haahr, Arne Nedergaard Kousholt, Halfdan Beck, Miranda J. Payne, Katsuhiro Hanada, Ian D. Hickson, Claus Storgaard S?rensen. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Nature Communications, 2013; 4: 1423 DOI: 10.1038/ncomms2395

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/4ezQqI79HWY/130129121933.htm

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Apple TV software update brings Bluetooth keyboard support, music from iTunes in the Cloud

Apple TV software update bring Bluetooth keyboard support, music from iTunes in the Cloud

It looks like the iPhone, iPad and iPod touch aren't the only Apple devices getting a software update today. The company has also rolled out an update to the Apple TV, which adds Bluetooth keyboard support, along with the ability to play music you've purchased from iTunes through iCloud. You'll also get a new "Up Next" feature that lets you choose what to play from the cued up music (or simply keep an eye on what's coming up).

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Source: 9 to 5 Mac

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/t8BX_CjZi54/

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Source: http://www.wallstreetoasis.com/blog/krawcheck-sell-side-er-best-job-out-of-college

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Monday, January 28, 2013

Accelerating neutral atoms on a table top

Jan. 27, 2013 ? Charged particle accelerators have become crucially important to modern day life, be it in health care for cancer treatment or for answering important fundamental scientific questions like the existence of the HIGGS boson, the so called 'God particle'.

In a simple picture, charged particles like electrons and protons are accelerated between two end plates across which an electrical voltage is applied. High energies need high voltages (millions and billions of volts) and long acceleration paths in giant sized machines -- for instance the trillion volt machine called the 'large hadron collider' (LHC) which discovered the Higgs boson, circles over 27 km underground in Geneva! A new concept for a compact accelerator was discovered in the last decade using high powered, short pulses of laser light.

Alternating large electric fields of the light can be transformed in plasmas to create quasi static fields that can produce hundreds of millions volt accelerating voltages just over millimeter lengths on a table top!

How do we accelerate neutral particles -- i.e. particles that cannot be energized by electrical voltages? And do it over millimeters rather than hundreds of meters and moreover using lasers? Research at Ultra Short Pulse High Intensity Lab in TIFR has now found a novel scheme that can do precisely this. The concept uses the ability of powerful lasers to strip nearly 8 electrons per atom in a nano sized, cooled aggregate of argon atoms- a nano piece of ice. A 40,000 atom cluster of argon is charged to 320,000 by a laser that lasts only a 100 billionth of a millionth of a second. Such a super highly charged ice piece explodes soon after, accelerating the charged atoms (Ions) to a million electron volts of energy. The TIFR research now found that all the expelled electrons can be put back into the charged ion that has been accelerated so that it now reverts to being a neutral atom but at high energies. To top it all, this process is nearly 100% efficient at neutralizing the speeding ions and converting them to fast atoms.

Accelerated neutral atoms are very important for many applications. Unaffected by electric or magnetic fields, they penetrate deeper in solids than electrons/ions and thereby create high finesse microstructures for novel electronics and optical devices. Fast atoms are used both as diagnostics and heating sources in Tokomak machines like the ITER (International Thermonuclear Experimental Reactor) in France, that are being developed to create sustained thermo-nuclear fusion. The TIFR scheme can produce a point source of fast neutral atoms close to the location of an intended application.

This certainly shows that staying neutral under extreme provocation has its advantages.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/electricity/~3/k-thzKvbSYA/130127134204.htm

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Climate change projected to alter Indiana bat maternity range

Climate change projected to alter Indiana bat maternity range [ Back to EurekAlert! ] Public release date: 28-Jan-2013
[ | E-mail | Share Share ]

Contact: Susan Loeb
sloeb@fs.fed.us
864-656-4865
USDA Forest Service ? Southern Research Station

Research by US Forest Service scientists forecasts profound changes over the next 50 years in the summer range of the endangered Indiana bat. In an article published in the journal Ecology and Evolution, Forest Service Southern Research Station researchers Susan Loeb and Eric Winters discuss the findings of one of the first studies designed to forecast the responses of a temperate zone bat species to climate change.

The researchers modeled the current maternity distribution of Indiana bats and then modeled future distributions based on four different climate change scenarios. "We found that due to projected changes in temperature, the most suitable summer range for Indiana bats would decline and become concentrated in the northeastern United States and the Appalachian Mountains," says SRS research ecologist Loeb. "The western part of the range (Missouri, Iowa, Illinois, Kentucky, Indiana, and Ohio)currently considered the heart of Indiana bat maternity rangewould become unsuitable under most climates that we modeled. This has important implications for managers in the Northeast and the Appalachian Mountains as these areas will most likely serve as climatic refuges for these animals when other parts of the range become too warm."

In general, bat species in temperate zones such as Indiana bats may be more sensitive than many other groups of mammals to climate change because their reproductive cycles, hibernation patterns, and migration are closely tied to temperature. Indiana bat populations were in decline for decades due to multiple factors, including the destruction of winter hibernation sites and loss of summer maternity habitat.

Due to conservation efforts, researchers saw an increase in Indiana bat populations in 2000 to 2005, but with the onset of white-nose syndrome populations are declining again, with the number of Indiana bats reported hibernating in the northeastern United States down by 72 percent in 2011. The study predicts even more declines due to temperature rises from climate change, with much of the western portion of the current range forecast to be unsuitable for maternity habitat by 2060.

"Our model suggests that once average summer (May through August) maximum temperatures reach 27.4C (81.3F), the climatic suitability of the area for Indiana bat maternity colonies declines," says Loeb. "Once they reach 29.9C (85.8F), the area is forecast to become completely unsuitable. Initially, Indiana bat maternity colonies may respond to warming temperatures by choosing roosts that have more shade than the roosts that they currently use. Eventually, it is likely that they will have to find more suitable climates."

The models the researchers produced provide resource managers guidance on areas that are likely to contain maternity colonies now and in the future, depending on the availability of suitable habitat in those areas. "Managers in the western parts of the range should be aware of the potential changes in summer distributions due to climate change and not assume that declines are due to habitat loss or degradation," says Loeb. "Management actions that foster high reproductive success and survival will be critical for the conservation and recovery of the species."

###

Access the full text of the article: http://onlinelibrary.wiley.com/doi/10.1002/ece3.440/abstract

Headquartered in Asheville, NC, the Southern Research Station comprises more than 120 scientists and several hundred support staff who conduct natural resource research in 20 locations across 13 southern states (Virginia to Texas). The Station's mission is "to create the science and technology needed to sustain and enhance southern forest ecosystems and the benefits they provide." Learn more about the Southern Research Station at: http://www.srs.fs.usda.gov/.


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Climate change projected to alter Indiana bat maternity range [ Back to EurekAlert! ] Public release date: 28-Jan-2013
[ | E-mail | Share Share ]

Contact: Susan Loeb
sloeb@fs.fed.us
864-656-4865
USDA Forest Service ? Southern Research Station

Research by US Forest Service scientists forecasts profound changes over the next 50 years in the summer range of the endangered Indiana bat. In an article published in the journal Ecology and Evolution, Forest Service Southern Research Station researchers Susan Loeb and Eric Winters discuss the findings of one of the first studies designed to forecast the responses of a temperate zone bat species to climate change.

The researchers modeled the current maternity distribution of Indiana bats and then modeled future distributions based on four different climate change scenarios. "We found that due to projected changes in temperature, the most suitable summer range for Indiana bats would decline and become concentrated in the northeastern United States and the Appalachian Mountains," says SRS research ecologist Loeb. "The western part of the range (Missouri, Iowa, Illinois, Kentucky, Indiana, and Ohio)currently considered the heart of Indiana bat maternity rangewould become unsuitable under most climates that we modeled. This has important implications for managers in the Northeast and the Appalachian Mountains as these areas will most likely serve as climatic refuges for these animals when other parts of the range become too warm."

In general, bat species in temperate zones such as Indiana bats may be more sensitive than many other groups of mammals to climate change because their reproductive cycles, hibernation patterns, and migration are closely tied to temperature. Indiana bat populations were in decline for decades due to multiple factors, including the destruction of winter hibernation sites and loss of summer maternity habitat.

Due to conservation efforts, researchers saw an increase in Indiana bat populations in 2000 to 2005, but with the onset of white-nose syndrome populations are declining again, with the number of Indiana bats reported hibernating in the northeastern United States down by 72 percent in 2011. The study predicts even more declines due to temperature rises from climate change, with much of the western portion of the current range forecast to be unsuitable for maternity habitat by 2060.

"Our model suggests that once average summer (May through August) maximum temperatures reach 27.4C (81.3F), the climatic suitability of the area for Indiana bat maternity colonies declines," says Loeb. "Once they reach 29.9C (85.8F), the area is forecast to become completely unsuitable. Initially, Indiana bat maternity colonies may respond to warming temperatures by choosing roosts that have more shade than the roosts that they currently use. Eventually, it is likely that they will have to find more suitable climates."

The models the researchers produced provide resource managers guidance on areas that are likely to contain maternity colonies now and in the future, depending on the availability of suitable habitat in those areas. "Managers in the western parts of the range should be aware of the potential changes in summer distributions due to climate change and not assume that declines are due to habitat loss or degradation," says Loeb. "Management actions that foster high reproductive success and survival will be critical for the conservation and recovery of the species."

###

Access the full text of the article: http://onlinelibrary.wiley.com/doi/10.1002/ece3.440/abstract

Headquartered in Asheville, NC, the Southern Research Station comprises more than 120 scientists and several hundred support staff who conduct natural resource research in 20 locations across 13 southern states (Virginia to Texas). The Station's mission is "to create the science and technology needed to sustain and enhance southern forest ecosystems and the benefits they provide." Learn more about the Southern Research Station at: http://www.srs.fs.usda.gov/.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/ufs-ccp012813.php

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Sunday, January 27, 2013

Top 7 Seo Tips That Make The Website Into Google Top 10 | THMG ...

Sunday, January 27th, 2013

1.Examining for a good place: It is very much compulsory to develop yourself as a professional in the arena. All the individuals will look for your website when you become trustworthy over the position.

2.Researching the keyword: Always remember that do not go for the most searched keyword, as it occupy a tough competition. Always try to stay away from such competitive keywords. You should opt for the long tail keywords as they have less competition and are more embattled

3.Submission of the articles: Write the articles about any of your choicest

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